Theses Topics


In addition to teaching chemical subjects for all three faculties of MENDELU, our Institute of Chemistry and Biochemistry ensures also the guidance of final theses, and namely for theachelor´s degree, master´s degree and for postgraduate doctoral studies.


Listed topics of final theses

It is recommendable to consult the potential supervisor or expert for guiding in the chosen field prior to applying for a concrete topic.  An already listed topic can be adapted (or a new topic listed) with regard to some specific experience or preference of the student in case of a timely consultation. We can also offer an unbinding visit for learning to know the workplace, during which possible details relating to particular topics can be discussed. If you feel attracted by the profile of a lab or another or if you are interested in certain topics in question, do not hesitate to make use of the e-mail addresses of concrete research group.

 

Research group of bioanalysis and genetic engineering

  • Optional topic.

Research group of molecular biology and nanomedicine

  • Optional topic.

Research group of synthesis and chemical analysis

  • Development of microfluidic Lab-on-a-chip exploiting magnetic nanoparticles for biogenic amines. Show Abstract

    For more than a decade, it has been expected that microfluidic technology would revolutionize the industry with simple, inexpensive, effective, and ubiquitous miniature diagnostic devices. To date, however, microfluidics has not yet been able to live up to these expectations. Despite tremendous progress in the field in the past decade, it seems that microfluidics has yet to live up to these expectations. The aim is to raise the new solution for design a fast and low-cost method based on microfluidic platform for biogenic amines identification employing magnetic isolation and electrochemical determination. Biologically active amine is normally present in the body and it is involved in a local regulation of physiological processes. It occurs in food as a product of microbial decarboxylation of the amino acid, and the ingestion of foods that contain high levels of amines can lead to poisoning. Hence, the presence of this biogenic amine is considered as an indicator of food spoilage.

  • Synthesis of potential antimicrobial peptides and study of bacterial resistance mechanisms and enzymatic activity. Show Abstract

    Antimicrobial peptides (AMPs) have been considered as promising candidates to treat infections caused by pathogenic bacteria to animals and humans. This assumption is based on their mechanism of action, which is mainly performed through electrostatic membrane interactions. Unfortunately, the rise in the reports that describe bacterial resistance to AMPs has reddened their role as therapeutic agents. In this study, we will focuses to investigate the resistance mechanisms developed by bacteria to AMPs, making special emphasis on resistance selection. Considering most of the resistance mechanisms here reviewed, the emergence of resistance is unlikely in the short term; however we will also described evidences that show the evolution of resistance to AMPs, reevaluating their use as good antibacterial agents. Finally, the knowledge related to the description of AMPs resistance mechanisms may provide useful information for improving strategies to control infections.

  • Electrochemical detection of bacteria using the nanomaterials. Show Abstract

    Overuse of antibiotics for the treatment of bacteria, leads towards evolution of antibiotic resistant bacteria which is a concerning health issue for the world. Quantitative estimation of bacteria is necessary from the overuse of drugs and bacterial evolution. PCR and traditional plate counting are complicated procedures and the choice to prescribe antibiotics is rarely based on definitive diagnoses. Thus an effective, rapid, low-cost diagnostic tools are needed for guiding optimal use of antibiotics in human and animal medicine and, also in the form of point-of-care (POC) devices. The nanotechnology has proven to be extremely successful in providing innovative and advantageous solutions to overcome the conventional in vitro diagnostic intrinsic limitations.

  • Label-free electrochemical aptasensor for detection of cancer biomarker. Show Abstract

    Cancer is a major global health problem in all regions of the world. If the cancer could be diagnosed at early stages, its treatment would be more effective. Short and stable single-stranded DNA or RNA sequences which are known as oligonucleotide aptamers are able to bind specifically to proteins, drugs and other organic or inorganic molecules with high specificity and affinity. Therefore, aptamers can be used as molecular recognition elements in biosensing application.

  • Development of microfluidic Lab-on-a-chip exploiting magnetic nanoparticles for biogenic amines. Show Abstract

    For more than a decade, it has been expected that microfluidic technology would revolutionize the industry with simple, inexpensive, effective, and ubiquitous miniature diagnostic devices. To date, however, microfluidics has not yet been able to live up to these expectations. Despite tremendous progress in the field in the past decade, it seems that microfluidics has yet to live up to these expectations. The aim is to raise the new solution for design a fast and low-cost method based on microfluidic platform for biogenic amines identification employing magnetic isolation and electrochemical determination. Biologically active amine is normally present in the body and it is involved in a local regulation of physiological processes. It occurs in food as a product of microbial decarboxylation of the amino acid, and the ingestion of foods that contain high levels of amines can lead to poisoning. Hence, the presence of this biogenic amine is considered as an indicator of food spoilage.

  • Synthesis of potential antimicrobial peptides and study of bacterial resistance mechanisms and enzymatic activity. Show Abstract

    Antimicrobial peptides (AMPs) have been considered as promising candidates to treat infections caused by pathogenic bacteria to animals and humans. This assumption is based on their mechanism of action, which is mainly performed through electrostatic membrane interactions. Unfortunately, the rise in the reports that describe bacterial resistance to AMPs has reddened their role as therapeutic agents. In this study, we will focuses to investigate the resistance mechanisms developed by bacteria to AMPs, making special emphasis on resistance selection. Considering most of the resistance mechanisms here reviewed, the emergence of resistance is unlikely in the short term; however we will also described evidences that show the evolution of resistance to AMPs, reevaluating their use as good antibacterial agents. Finally, the knowledge related to the description of AMPs resistance mechanisms may provide useful information for improving strategies to control infections.